A Surprising New Arrhythmia Mechanism in Heart Failure
نویسندگان
چکیده
منابع مشابه
A surprising new arrhythmia mechanism in heart failure.
Heart failure is the most common discharge diagnosis in the United States, with a prognosis worse than many cancers.1 Patients with heart failure die for two reasons: advanced circulatory insufficiency or sudden death.2 We know that continuous online monitoring of cardiac rhythm from patients with advanced heart failure is inevitably abnormal and often shows long runs of irregular and/or polymo...
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In contrast to systolic heart failure (SHF), for which knowledge of pathophysiology and therapy has advanced rapidly over the past decade, little is known about diastolic heart failure (DHF). The article by van Heerebeek et al1 in this issue of Circulation that describes an abnormal distribution of titin isoforms in DHF may herald a new approach to understanding the pathophysiology of this synd...
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The peak sodium current underlies excitability and conduction in heart muscle, but a late sodium current flowing after the peak contributes to maintaining and prolonging the action potential plateau, and also to intracellular sodium loading, which in turn increases intracellular calcium with consequent effects on arrhythmia and diastolic function. Late sodium current is pathologically increased...
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Heart failure (HF) affects more than 5 million Americans, and acute decompensated heart failure (ADHF) has emerged as the leading cause of hospitalization among people over the age of 65 years.1 Importantly, HF is a leading public health concern, and hospitalization expenses related to management of ADHF impose a substantial financial burden on the health care system. Additionally, readmission ...
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Recently, we found that repolarization heterogeneities between subepicardial and midmyocardial cells can form a substrate for reentrant ventricular arrhythmias in failing myocardium. We hypothesized that the mechanism responsible for maintaining transmural action potential duration heterogeneities in heart failure is related to intercellular uncoupling from downregulation of cardiac gap junctio...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2003
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000095382.50153.7d